Generalized Anxiety Disorder Is Associated With Overgeneralization of Classically Conditioned Fear

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Generalized anxiety disorder is associated with overgeneralization of classically conditioned fear.

BACKGROUND Meta-analytic results of fear-conditioning studies in the anxiety disorders implicate generalization of conditioned fear to stimuli resembling the conditioned danger cue as one of the more robust conditioning markers of anxiety pathology. Due to the absence of conditioning studies assessing generalization in generalized anxiety disorder (GAD), results of this meta-analysis do not rev...

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Conditioned Fear Acquisition and Generalization in Generalized Anxiety Disorder.

Abnormal fear conditioning processes (including fear acquisition and conditioned fear-generalization) have been implicated in the pathogenesis of anxiety disorders. Previous research has shown that individuals with panic disorder present enhanced conditioned fear-generalization in comparison to healthy controls. Enhanced conditioned fear-generalization could also characterize generalized anxiet...

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Overgeneralization of conditioned fear as a pathogenic marker of panic disorder.

OBJECTIVE Classical conditioning features prominently in many etiological accounts of panic disorder. According to such accounts, neutral conditioned stimuli present during panic attacks acquire panicogenic properties. Conditioned stimuli triggering panic symptoms are not limited to the original conditioned stimuli but are thought to generalize to stimuli resembling those co-occurring with pani...

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PS24. Neural Circuitry of Over-Generalization of Conditioned Fear in Generalized Anxiety Disorder

Background: Health anxiety (HA) is common in asthmatic patients. But the biological underpinnings of HA in asthmatic patients remains unknown. Therefore, the aim of this study is to discover the brain regional homogeneity (ReHo) underlying asthma and HA. Methods: 28 patients and 30 ageand gendermatched controls received resting-state functional magnetic resonance imaging (rs-fMRI) scan and HA a...

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Generalized implicit fear associations in generalized anxiety disorder.

BACKGROUND Cognitive schema theories of anxiety postulate that higher-level cognitive processes such as attention and memory are guided by underlying distorted fear associations. While numerous studies investigated these disorder-specific, biased processes, hardly any research addressed the underlying schemata themselves. In particular, no study has ever addressed implicit fear associations in ...

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ژورنال

عنوان ژورنال: Biological Psychiatry

سال: 2014

ISSN: 0006-3223

DOI: 10.1016/j.biopsych.2013.07.025